Benadryl side effects long term - Diphenhydramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, itching, watery eyes, itchy eyes /nose/throat, cough, runny ...

 
Feb 18, 2010 · One Benadryl per night seems to be enough to keep the ears dry & the resulting nausea at bay. I must admit that I'm not sure this is still even a problem for me. The last time I stopped to see if I still needed it was about 2 years ago. After 3 days, the dizziness/nausea/inner ear issues came back, so I promptly started taking the nightly ... . 2f gems luigi

Jun 28, 2021 · Experts say skip antihistamines. Dana Benson. 713-798-8267. Houston, TX - Jun 28, 2021. Share this article. For people who take an antihistamine such as Benadryl for a cold or allergies, drowsiness is often a welcome side effect. But a Baylor College of Medicine sleep expert cautions against turning to this type of medication as a sleep aid. Jun 15, 2016 · IV administration of 50 mg of DPH resulted in immediate improvement of tremor, rigidity, tachycardia, and eye versions. The patient was started on oral DPH 50 mg 4 times a day and the dose was reduced by 25% every 3 days. Oral clonidine 0.1 mg 3 times a day and a weekly 0.1 mg transdermal patch was added to mitigate sympathetic side effects. May 8, 2019 · Answer. While Benadryl ( diphenhydramine) can safely be used once in a while as a sleep aid, long-term use is not recommended for multiple reasons. Even the intermittent use of Benadryl for sleep isn't generally recommended if you are elderly (over 65). Studies show that the elderly population doesn't metabolize Benadryl as quickly and are far ... Aug 25, 2021 · Examples of Viagra’s more commonly reported side effects include: headache. flushing (temporary warmth, redness, or deepening of skin color) stuffy nose. indigestion (upset stomach) mild vision ... and readily penetrates the blood-brain-barrier. Thus side effects such as grogginess, drowsiness, and memory loss are common. Diphenhydramine is also used for motion sickness and extrapyramidal symptoms in Parkinson’s disease patients. Potential harm to the brain: Long-term anticholinergic use has been associated with increased Long-term side effects Over-the-counter Benadryl is approved for temporary or short-term use and is not intended for long-term use. There is very little scientific research about the long-term ...Aug 23, 2021 · Symptoms can be mild or serious and can include: skin rash. itchiness. flushing (temporary warmth, redness, or deepening of skin color) swelling under your skin, typically in your eyelids, lips, hands, or feet. swelling of your mouth, tongue, or throat, which can make it hard to breathe. Dizziness Nausea or vomiting Loss of appetite Constipation Increased chest congestion Headache Excitability (especially in children) Nervousness Benadryl can impair mental and motor functioning, as well as your performance at work or school. It can also impair a person’s ability to operate a motor vehicle or other potentially dangerous equipment.Uses Diphenhydramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, itching, watery eyes, itchy eyes /nose/throat, cough,...Common Benadryl (diphenhydramine) side effects include drowsiness, dizziness, and blurry vision. Dry mouth and constipation are common, as well. Serious Benadryl side effects include a greater risk of falls — especially if you are an older adult — and potential long-term memory problems.Jun 28, 2021 · Experts say skip antihistamines. Dana Benson. 713-798-8267. Houston, TX - Jun 28, 2021. Share this article. For people who take an antihistamine such as Benadryl for a cold or allergies, drowsiness is often a welcome side effect. But a Baylor College of Medicine sleep expert cautions against turning to this type of medication as a sleep aid. Uses Diphenhydramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, itching, watery eyes, itchy eyes /nose/throat, cough,...Yes, certain side effects may be possible with long-term use of Benadryl. However, doctors usually don’t recommend Benadryl for long-term use. Instead, they typically advise short-term use of the drug to ease certain symptoms. The drug’s label information* for Benadryl does not specify any long-term side effects for this drug.Oct 6, 2015 · Caution should be exercised for long-term use of Benadryl (diphenhydramine), an antihistamine and a non-benzodiazepine sedative-hypnotic, because of the association of increased risk for dementia. Benadryl dosage for dogs. The correct dosage of diphenhydramine for dogs depends on their weight. A small dog will need much less than a big dog to receive the same positive effects. According to ...Side effects of antihistamines that make you drowsy can include: sleepiness (drowsiness) and reduced co-ordination, reaction speed and judgement – do not drive or use machinery after taking these antihistamines. dry mouth. blurred vision. difficulty peeing. Side effects of non-drowsy antihistamines can include: headache.May 25, 2023 · Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes. Not able to pass urine or change in how much urine is passed. A very bad skin reaction ( Stevens-Johnson syndrome / toxic epidermal necrolysis) may happen. Examples of Viagra’s more commonly reported side effects include: headache. flushing (temporary warmth, redness, or deepening of skin color) stuffy nose. indigestion (upset stomach) mild vision ...Diphenhydramine or : Benadryl (diphenhydramine) may cause sedation the next day (due to its long half-life), decreased alertness, diminished cognitive function, delirium, ... Read More. Created for people with ongoing healthcare needs but benefits everyone. Learn how we can help. 5k views Reviewed >2 years ago.Benadryl dosage for dogs. The correct dosage of diphenhydramine for dogs depends on their weight. A small dog will need much less than a big dog to receive the same positive effects. According to ...Section snippets Sedation. The sedation associated with diphenhydramine is one of the most acknowledged effects of this medication. Indeed, it is frequently used as a medication to treat insomnia. 3 The sedative effect of diphenhydramine is related to its easy penetration of the blood-brain barrier. 4 In the brain, diphenhydramine interferes with H 1 receptors, which causes drowsiness and ...Side effects of antihistamines that make you drowsy can include: sleepiness (drowsiness) and reduced co-ordination, reaction speed and judgement – do not drive or use machinery after taking these antihistamines. dry mouth. blurred vision. difficulty peeing. Side effects of non-drowsy antihistamines can include: headache.Nov 15, 2017 · Asthma. Car Sickness. Insomnia. Motion sickness. Reactions to Vaccines. Because one of the common side effect of Benadryl in dogs is drowsiness, your vet may use it to alleviate dog anxiety, particularly associated with traveling and motion sickness that may occur during plane rides or car trips. and readily penetrates the blood-brain-barrier. Thus side effects such as grogginess, drowsiness, and memory loss are common. Diphenhydramine is also used for motion sickness and extrapyramidal symptoms in Parkinson’s disease patients. Potential harm to the brain: Long-term anticholinergic use has been associated with increasedWhen corrected based on the number of drugs with anticholinergic effects an individual was taking, the odds ratio for cognitive impairment was 1.46 with a p value of .0181. However, overall the authors conclude that their data did not support the hypothesis that the use of anticholinergic medications increased the risk of alzheimer’s dementia ...Apr 8, 2023 · The main long-term side effects of Plaquenil are eye-related. ... To manage your symptoms, they may suggest an over-the-counter antihistamine you take by mouth, such as Benadryl (diphenhydramine ... Common Benadryl (diphenhydramine) side effects include drowsiness, dizziness, and blurry vision. Dry mouth and constipation are common, as well. Serious Benadryl side effects include a greater risk of falls — especially if you are an older adult — and potential long-term memory problems.Common Side Effects of Diphenhydramine. Diphenhydramine is considered an H1 receptor antagonist, and it works by blocking the effect of histamine in the body. The chemical reactions that diphenhydramine trigger in the body can cause other potentially significant sedative side effects on the central nervous system (CNS).The main long-term side effects of Plaquenil are eye-related. ... To manage your symptoms, they may suggest an over-the-counter antihistamine you take by mouth, such as Benadryl (diphenhydramine ...Apr 11, 2018 · Benadryl is a first-generation antihistamine, meaning it is one of the earlier drugs developed in this category of medications. First-generation antihistamines, like Benadryl, are often noted for their sedative side effects as they have the ability to travel to your brain (i.e. crosses the blood-brain barrier), which is why they can make you ... Aug 25, 2021 · Examples of Viagra’s more commonly reported side effects include: headache. flushing (temporary warmth, redness, or deepening of skin color) stuffy nose. indigestion (upset stomach) mild vision ... Dizziness Nausea or vomiting Loss of appetite Constipation Increased chest congestion Headache Excitability (especially in children) Nervousness Benadryl can impair mental and motor functioning, as well as your performance at work or school. It can also impair a person’s ability to operate a motor vehicle or other potentially dangerous equipment.Jun 5, 2019 · Addiction and Misuse. Another cause of overdose is an addiction to Diphenhydramine. Patients can become addicted to Benadryl after taking it for an extended period or when it is used for recreational purposes. Side effects of Diphenhydramine overdose often cause long-term damage, which can be fatal to patients ingesting it. Potential Kidney Risks. Yes, long-term use of Benadryl can put strain on the kidneys, as it can build up in the system. This can cause toxicity and potentially lead to kidney damage. It's important to be aware of the potential side effects of long-term use and to consult a doctor if any symptoms arise.Feb 18, 2010 · One Benadryl per night seems to be enough to keep the ears dry & the resulting nausea at bay. I must admit that I'm not sure this is still even a problem for me. The last time I stopped to see if I still needed it was about 2 years ago. After 3 days, the dizziness/nausea/inner ear issues came back, so I promptly started taking the nightly ... Jun 6, 2023 · Benadryl may cause serious side effects including: pounding heartbeats or fluttering in your chest, painful or difficult urination, little or no urination, confusion, lightheadedness, tightness in your neck or jaw, and. uncontrollable movements of your tongue. Get medical help right away, if you have any of the symptoms listed above. While there are cases of misuse and abuse, withdrawal symptoms from Benadryl are rare, even with long term use. Nevertheless, Benadryl has strong anticholinergic effects, and there have been reports of 'anticholinergic withdrawal' in some individuals taking Benadryl for extended periods of time. Potential symptoms include:“The antihistamine diphenhydramine is only approved for management of short-term or temporary sleep difficulties, particularly in those people who have problems falling asleep,” Dr. What are the negative effects of Benadryl? Drowsiness, dizziness, constipation, stomach upset, blurred vision, or dry mouth/nose/throat may occur. If any of ...Feb 18, 2010 · One Benadryl per night seems to be enough to keep the ears dry & the resulting nausea at bay. I must admit that I'm not sure this is still even a problem for me. The last time I stopped to see if I still needed it was about 2 years ago. After 3 days, the dizziness/nausea/inner ear issues came back, so I promptly started taking the nightly ... Benadryl dosage for dogs. The correct dosage of diphenhydramine for dogs depends on their weight. A small dog will need much less than a big dog to receive the same positive effects. According to ...This video examines the question and remark: Benadryl long term side effects! I WISH I had KNOWN! Benadryl is a common OTC medication and is also known as D...Benadryl is a brand of diphenhydramine. As far as long term effects. Look up Benadryl or diphenhydramine and dementia on google then come back to me. I am a 10 year 50mg daily user of diphenhydramine and am slowly stopping this stuff. The past few weeks I have been reducing to 1/2. Trust me, take this for long term and you increase risk of ...May 8, 2019 · Answer. While Benadryl ( diphenhydramine) can safely be used once in a while as a sleep aid, long-term use is not recommended for multiple reasons. Even the intermittent use of Benadryl for sleep isn't generally recommended if you are elderly (over 65). Studies show that the elderly population doesn't metabolize Benadryl as quickly and are far ... Mar 21, 2023 · There is very little scientific research about the long-term effects of Benadryl. Some side effects that may occur with long-term use include: constipation; blurred vision Anxiety. Asthma. Car Sickness. Insomnia. Motion sickness. Reactions to Vaccines. Because one of the common side effect of Benadryl in dogs is drowsiness, your vet may use it to alleviate dog anxiety, particularly associated with traveling and motion sickness that may occur during plane rides or car trips.Jul 7, 2022 · Advertisement constipation. blurred vision. memory problems and dementia (especially in seniors) anxiety. dependence. What are the side effects of taking Benadryl every night? SIDE EFFECTS: Drowsiness, dizziness, constipation, stomach upset, blurred vision, or dry mouth/nose/throat may occur. If any of these effects persist or worsen, tell your doctor or pharmacistRead More → Long term use of some antihistamines may increase your risk of dementia. Diphenhydramine (Benadryl®) blocks the effects of a neurotransmitter called acetylcholine. This neurotransmitter is vital for memory and learning. Diphenhydramine increased the risk of dementia by 54% in one 3,000 patient study followed for seven years. Jul 9, 2015 · Higher dosage or long-term use of common drugs with anticholinergic effects is linked to significantly increased risk of dementia - including Alzheimer’s - says large study. Aug 15, 2023 · It can sometimes cause a decrease in memory, confusion, and thinking issues. These side effects are more common in elders. In addition, taking Benadryl long-term might increase the risk of dementia. People aged> 65 who took medications such as Benadryl daily for over three years had an increased risk of dementia. Diphenhydramine is contraindicated in premature infants and neonates, as well as people who are breastfeeding. It is a pregnancy Category B drug. Diphenhydramine has additive effects with alcohol and other CNS depressants. Monoamine oxidase inhibitors prolong and intensify the anticholinergic effect of antihistamines. OverdoseImpaired concentration. Memory difficulties. Anxiety. Stomach disturbances. Nausea and vomiting. A dry mouth. Constipation. Liver problems, etc. In certain people, a paradoxical reaction to diphenhydramine is possible, meaning that the drug causes different symptoms than the intended ones.IV administration of 50 mg of DPH resulted in immediate improvement of tremor, rigidity, tachycardia, and eye versions. The patient was started on oral DPH 50 mg 4 times a day and the dose was reduced by 25% every 3 days. Oral clonidine 0.1 mg 3 times a day and a weekly 0.1 mg transdermal patch was added to mitigate sympathetic side effects.Diphenhydramine blocks the effects of histamine in your brain and this reduces symptoms. It enters the brain in large quantities and this can make you feel drowsy. Diphenhydramine also blocks the effects of another chemical called acetylcholine. This can help a cough or runny nose but can also cause side effects such as a dry mouth and dry nose.While it may work to help you fall asleep for a few days, long-term use of Benadryl as a sleep-aid likely isn't effective and is associated with several side effects like next-day drowsiness. Additionally, the long-term use of drugs like Benadryl in those 65 years old and over is linked with an increased risk of dementia.There could be both short- and long-term consequences. Worried about the side effects of Ambien, Lunesta or other sleep aids? ... Diphenhydramine is an anticholinergic drug, which means it blocks ...There could be both short- and long-term consequences. Worried about the side effects of Ambien, Lunesta or other sleep aids? ... Diphenhydramine is an anticholinergic drug, which means it blocks ...It can sometimes cause a decrease in memory, confusion, and thinking issues. These side effects are more common in elders. In addition, taking Benadryl long-term might increase the risk of dementia. People aged> 65 who took medications such as Benadryl daily for over three years had an increased risk of dementia.Besides having side effects including drowsiness, confusion, and urinary retention, a new study shows that frequent, long-term use of older antihistamines are associated with an increased risk of ...Warnings What to ask your doctor Q&A Benadryl (diphenhydramine) is used for allergies and allergic reactions, as well as common cold symptoms. Benadryl can cause mild or serious side...January 19, 2022. By Harvard Health Publishing Staff. A report published in JAMA Internal Medicine several years ago highlighted a link between long-term use of anticholinergic medications like Benadryl and dementia. While this study and other observational studies have also found this association, it doesn't prove that these drugs cause dementia.Answer From Eric J. Olson, M.D. It's unlikely you'll become dependent on zolpidem (Ambien). Ambien and similar sleep medications can be effective, and they're much less likely to be habit-forming than some other drugs sometimes prescribed for sleep problems — for example, benzodiazepines, such as alprazolam (Xanax), lorazepam (Ativan) or ...Long-term use of Benadryl can also lead to constipation and confusion. Interactions. Benadryl containing diphenhydramine can interact with alcohol as both are central nervous system (CNS) depressants. Side effects such as drowsiness and dizziness may be enhanced when taking alcohol with diphenhydramine.Oct 3, 2022 · Applies to diphenhydramine: oral capsules and tablets, parenteral injection. Side effects include: Sedation, sleepiness, dizziness, disturbed coordination, epigastric distress, thickening of bronchial secretions. Jan 24, 2018 · Taking an over-the-counter sleep aid with diphenhydramine once in a while is generally not going to cause problems, other than a possible hangover the next day. Older people, however, can get confused when taking diphenhydramine because it also blocks a brain chemical called acetylcholine, which plays a big role in attention and short-term memory. feeling of warmth, redness of the face, neck, arms and occasionally, upper chest. large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs. shortness of breath, difficult or labored breathing. Some side effects may occur that usually do not need medical attention.Long-term side effects Over-the-counter Benadryl is approved for temporary or short-term use and is not intended for long-term use. There is very little scientific research about the long-term ...Yes, certain side effects may be possible with long-term use of Benadryl. However, doctors usually don’t recommend Benadryl for long-term use. Instead, they typically advise short-term use of the drug to ease certain symptoms. The drug’s label information* for Benadryl does not specify any long-term side effects for this drug.“The antihistamine diphenhydramine is only approved for management of short-term or temporary sleep difficulties, particularly in those people who have problems falling asleep,” Dr. What are the negative effects of Benadryl? Drowsiness, dizziness, constipation, stomach upset, blurred vision, or dry mouth/nose/throat may occur. If any of ...Uses Diphenhydramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, itching, watery eyes, itchy eyes /nose/throat, cough,... Hives. Swelling and inflammation. Redness. Runny nose and eyes. Coughing. Sneezing. Anaphylactic reaction. One of the side effects of Benadryl is drowsiness, which can help to calm anxious dogs ...Official answer. Diphenhydramine can be used as a short-term sleep aid to help ease occasional sleep problems. Older adults, children under age 16 and pregnant women should avoid taking diphenhydramine, as the risks to these groups may outweigh the benefits. Diphenhydramine should not be taken as a treatment for chronic insomnia. Hives. Swelling and inflammation. Redness. Runny nose and eyes. Coughing. Sneezing. Anaphylactic reaction. One of the side effects of Benadryl is drowsiness, which can help to calm anxious dogs ...Section snippets Sedation. The sedation associated with diphenhydramine is one of the most acknowledged effects of this medication. Indeed, it is frequently used as a medication to treat insomnia. 3 The sedative effect of diphenhydramine is related to its easy penetration of the blood-brain barrier. 4 In the brain, diphenhydramine interferes with H 1 receptors, which causes drowsiness and ...Jun 15, 2016 · IV administration of 50 mg of DPH resulted in immediate improvement of tremor, rigidity, tachycardia, and eye versions. The patient was started on oral DPH 50 mg 4 times a day and the dose was reduced by 25% every 3 days. Oral clonidine 0.1 mg 3 times a day and a weekly 0.1 mg transdermal patch was added to mitigate sympathetic side effects. Oct 9, 2018 · Many older adults may take sleeping pills because pain, nerve problems or other health issues are keeping them up at night, she says. For these people, a sleeping pill is standing in the way of ... While there are cases of misuse and abuse, withdrawal symptoms from Benadryl are rare, even with long term use. Nevertheless, Benadryl has strong anticholinergic effects, and there have been reports of 'anticholinergic withdrawal' in some individuals taking Benadryl for extended periods of time. Potential symptoms include:Higher dosage or long-term use of common drugs with anticholinergic effects is linked to significantly increased risk of dementia - including Alzheimer’s - says large study.• Common side effects of montelukast include upper respiratory infection, fever, headache, sore throat, cough, stomach pain, diarrhea, earache or ear infection, flu, runny nose, and sinus infection. Answer From Eric J. Olson, M.D. It's unlikely you'll become dependent on zolpidem (Ambien). Ambien and similar sleep medications can be effective, and they're much less likely to be habit-forming than some other drugs sometimes prescribed for sleep problems — for example, benzodiazepines, such as alprazolam (Xanax), lorazepam (Ativan) or ...

Inhaled corticosteroids are often used daily as part of treatment for asthma caused or complicated by reactions to airborne allergy triggers (allergens). Side effects are generally minor and can include mouth and throat irritation and oral yeast infections. Some inhalers combine corticosteroids with long-acting bronchodilators.. Culverpercent27s chicken dinner discontinued

benadryl side effects long term

May 22, 2013 · When corrected based on the number of drugs with anticholinergic effects an individual was taking, the odds ratio for cognitive impairment was 1.46 with a p value of .0181. However, overall the authors conclude that their data did not support the hypothesis that the use of anticholinergic medications increased the risk of alzheimer’s dementia ... Diphenhydramine is a type of medicine called an antihistamine. It is used in some allergy and sleep medicines. Overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by accident or on purpose. This article is for information only. DO NOT use it to treat or manage an actual overdose.“The antihistamine diphenhydramine is only approved for management of short-term or temporary sleep difficulties, particularly in those people who have problems falling asleep,” Dr. What are the negative effects of Benadryl? Drowsiness, dizziness, constipation, stomach upset, blurred vision, or dry mouth/nose/throat may occur. If any of ...Mar 21, 2023 · There is very little scientific research about the long-term effects of Benadryl. Some side effects that may occur with long-term use include: constipation; blurred vision Feb 18, 2010 · One Benadryl per night seems to be enough to keep the ears dry & the resulting nausea at bay. I must admit that I'm not sure this is still even a problem for me. The last time I stopped to see if I still needed it was about 2 years ago. After 3 days, the dizziness/nausea/inner ear issues came back, so I promptly started taking the nightly ... Dizziness Nausea or vomiting Loss of appetite Constipation Increased chest congestion Headache Excitability (especially in children) Nervousness Benadryl can impair mental and motor functioning, as well as your performance at work or school. It can also impair a person’s ability to operate a motor vehicle or other potentially dangerous equipment.skin rash. swollen joints. stomach discomfort, upset or pain. tender swollen glands in neck. tremor. unusual excitement, nervousness, restlessness, or irritability. vomiting. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.Anxiety. Asthma. Car Sickness. Insomnia. Motion sickness. Reactions to Vaccines. Because one of the common side effect of Benadryl in dogs is drowsiness, your vet may use it to alleviate dog anxiety, particularly associated with traveling and motion sickness that may occur during plane rides or car trips.There could be both short- and long-term consequences. Worried about the side effects of Ambien, Lunesta or other sleep aids? ... Diphenhydramine is an anticholinergic drug, which means it blocks ...Diphenhydramine (Benadryl) is a common over-the-counter allergy medication. It’s part of a class of drugs called anticholinergics that research has linked to dementia in older people.Nov 24, 2022 · But it has quite a long list of possible side effects. In fact, the Canadian Society of Allergy and Clinical Immunology has given serious warnings about them, even for people. The organization issued a 2019 position statement about Benadryl. They advised against the drug because of the high risk of side effects and overdose. They said the drug ... Sep 4, 2023 · Impaired concentration. Memory difficulties. Anxiety. Stomach disturbances. Nausea and vomiting. A dry mouth. Constipation. Liver problems, etc. In certain people, a paradoxical reaction to diphenhydramine is possible, meaning that the drug causes different symptoms than the intended ones. hoarseness. lack or loss of strength. pain in the lower back or side. swelling of the hands, feet, or lower legs. trembling or shaking. Common side effects that do require medical attention ...Apr 11, 2018 · Benadryl is a first-generation antihistamine, meaning it is one of the earlier drugs developed in this category of medications. First-generation antihistamines, like Benadryl, are often noted for their sedative side effects as they have the ability to travel to your brain (i.e. crosses the blood-brain barrier), which is why they can make you ... Jan 6, 2023 · Diphenhydramine is a common ingredient in sleeping aids; it is also used to treat allergies. While effective, the risk of serious diphenhydramine side effects—including confusion, dizziness, urinary retention, and liver or kidney issues—is increased in people age 65 and older. Nov 14, 2022 · A 2017 study revealed that 10% of adults aged 18-45 use OTC sleep aids while 17.5% of people 65 years and older do. Most over-the-counter options are considered safe when used occasionally—as long as the medication is compatible with any medical conditions you have and other medications you take. But when taken night after night, trouble can ... May 8, 2019 · Answer. While Benadryl ( diphenhydramine) can safely be used once in a while as a sleep aid, long-term use is not recommended for multiple reasons. Even the intermittent use of Benadryl for sleep isn't generally recommended if you are elderly (over 65). Studies show that the elderly population doesn't metabolize Benadryl as quickly and are far ... Long-Term Side Effects of Diphenhydramine Abuse. Continued diphenhydramine use can cause long-term adverse side effects that result in permanent damage. Not only will prolonged use cause harm, but it can lead to other aspects such as dependence on the medication. Common long-term side effects of prolonged diphenhydramine use include: Dependence. Benadryl and Depression. Although there is no direct effect of Benadryl on depression, regular and daily use of Benadryl does result in severe depression in the individual. It is believed to be helpful only for the short term, however, long term use of Benadryl results in certain depressive symptoms in the individual..

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